Crafting a Career with Purpose: Pathway from LFS to Environmental Innovation

Sequencing Genes in Yeast Isolated from B.C. Wine Grapes

New Yeast Discovered in B.C. Wineries

UBC researchers are using genomics to isolate new yeasts that impart a flavour profile specific to B.C. soils.

For hundreds of years, humans have used a certain species of yeast to brew beer and ferment wine. Saccharomyces cerevisiae (S. cerevisiae) is a powerhouse microorganism that is widely used for its reliability to convert the sugars in grapes into alcohol and create a consistent finished product.

However, some winemakers let the environment shape the flavour of their wines, using wild yeast to influence their fermentations. In the Okanagan Valley, Dr. Vivien Measday and her students have used whole genome sequencing to identify a new clade or family of wine yeast in BC vineyards and wineries.

Vivien Measday

“Yeast has been domesticated just like farm animals have,” Measday says. “These Pacific West Coast Wine yeasts are completely new! We are the first group to find wild S. cerevisiae strains in wine in Canada that are so different from European commercial strains.”

“Yeast is heavily involved in the flavour and aroma compounds of wine. A different genetic makeup could mean a novel flavour profile,” current PhD student Jay Martiniuk adds. “A profile that may be unique to B.C. growing regions.”

From her undergraduate in biochemistry to a PhD focused on S. cerevisiae as a model organism, Measday has spent over 30 years studying yeast. Now as an associate professor at the UBC Wine Research Centre, she is deeply interested in yeast diversity for applications in the wine industry.

Martiniuk brings industry experience to his research. After years of working in wineries, he entered UBC’s food science program to investigate the scientific why’s and how’s of winemaking. During his Master of Science program in Food Science, Martiniuk carried out the first wine grape yeast isolation research project in Measday’s lab. They have worked closely in wine sciences ever since.

The Process: From Field to Lab

The Measday lab tests samples from each step: from grapes sampled in the vineyard, to the initial crush of the grapes, then from early-, middle-, and late-stage fermentation. Researchers in the lab isolate dozens of yeast species and strains in each fermentation, noting which ones are able to outcompete and survive to the end product.

To get a full picture of the S. cerevisiae strains from each vineyard, Martiniuk developed a protocol that captures a DNA fingerprint of each yeast strain. He focuses on specific regions of the genome to categorize strains of similar makeup and differentiate strains that have been used commercially versus those that are unique.

“So much of this work is collaborating with wineries, who are looking to define their terroir,” Martiniuk says, referring to the environmental factors that affect a crop of wine grapes. “These wild yeasts may have a more unique winemaking traits, which could lead to a more interesting aroma and flavour profile in wines.”

Measday and Martiniuk have collected isolates of several thousand yeasts, and Measday’s lab has identified over 200 S. cerevisiae strains in the Okanagan Valley. After isolating and prioritizing the strains, the lab sends particularly novel strains to another centre for whole genome sequencing.

“They report back every single facet of the DNA sequence,” Measday says. “This detailed view can tell us how the yeast may perform in fermentation and what traits may allow it to survive in the environment.” Measday’s other students, PhD candidates Alex Marr and Jackson Moore, analyzed the whole genome sequencing data to identify this new family of Pacific West Coast Wine yeast.

The lab now has a collection of yeasts from the region. If they find a specific genetic makeup that delivers a preferred flavour profile, they can grow and potentially commercialize that strain.

Measday and Martiniuk have studied twelve vineyard sites and several different wineries in the Okanagan Valley. Their lab is now shifting towards Vancouver Island’s quickly growing wine industry.

“It’s geographically quite isolated from the rest of the province,” Martiniuk says. “We’re hoping that isolation has produced strains that are quite genetically different from the Valley.”

Although they have just started the DNA fingerprinting process on Vancouver Island, the lab has already seen a difference in yeast species. While the Okanagan Valley vineyards surveyed in their research were mostly populated by S. cerevisiae, Vancouver Island may also have other species such as Saccharomyces paradoxus and Saccharomyces uvarum. Martiniuk notes that S. uvarum behaves differently in fermentation, preferring colder temperatures as low as 12ºC compared to S. cerevisiae’s 25-30ºC range.

New Yeasts in B.C. Winemaking

Winemakers in B.C. have been excited to know what lives in their fields and tanks.

“It’s important to know what you want and don’t want in your tanks,” Measday says, explaining spontaneous fermentation, which uses wild yeasts. “The native microorganisms could overpower the wine or impart undesirable flavours altogether.”

One winery in the Okanagan, Okanagan Crush Pad, in collaboration with graduated MSc student Elia Castellanos, has already tested pilot-scale production with a couple of new Pacific West Coast Wine strains. Measday and Martiniuk hope that their research can add predictability and reliability to B.C.’s endemic yeasts.

Selected Papers:

Marr RA^, Moore J^, Formby S, Martiniuk JT, Hamilton J, Ralli S, Konwar K et al. Whole genome sequencing of Canadian Saccharomyces cerevisiae wine strains reveals four subpopulations with similarity to North American oak, sake, and commercial strains. G3: Genomes, Genes, Genetics, Volume 13, Issue 8, August 2023, jkad130

Cheng E^, Martiniuk JT^, Hamilton J, McCarthy GC, Castellarin SD, Measday V. 2020. Characterization of Sub-Regional Variation in Saccharomyces Populations and Grape Phenolic Composition in Pinot Noir Vineyards of a Canadian Wine Region. Frontiers in. Genetics. Aug 31; 11:908.

Martiniuk JT, Pacheco B, Russell G, Tong S, Backstrom I, Measday V. 2016. Impact of commercial strain use on Saccharomyces cerevisiae population structure and dynamics in Pinot Noir vineyards and spontaneous fermentations at a Canadian winery. PLOS ONE 11(8): e0160259.

More Research in Food Science

Kyrene Tey

About

NameKyrene Tey
PronounsShe / Her
DegreeBachelor of Science in Food, Nutrition and Health
MajorNutritional Sciences 
Year4
HometownKuala Lumpur, Malaysia
Transferred from:Taylor’s University Lakeside Campus, Malaysia

Turning a Passion for Food into Purpose

Kyrene Tey is an undergraduate student in the Food, Nutrition and Health program at UBC. Her passion for food started with watching cooking videos online and was further shaped by her mom’s consistent encouragement of healthy eating at home. These early influences sparked her curiosity about the role of nutrition in everyday life and motivated her to study it more deeply in the Faculty of Land and Food Systems (LFS).

Kyrene shares that “learning about nutrition helps us make informed choices that support both individual health and community well-being.” She encourages students to stay open to new interests and pathways, as they often lead to unexpected and rewarding opportunities.

What are three adjectives that describe you?

Fun, spontaneous, open-minded

Why did you choose to transfer to LFS?  

While I was exploring options for universities in North America to pursue my studies in food and nutrition, I came across the Faculty of Land and Food Systems at UBC. As I did my further research on this Faculty, I discovered that this program at UBC has a huge focus on integrating learning on sustainability, health and the science behind what we eat as a whole to make positive impacts through improving our current food systems, which is something that continues to interest me up until today.

What is the greatest advantage of studying in a smaller Faculty at UBC? 

You’ll get to know a lot of your peers and staff, and you will also have the chance to build closer connections with professors here in LFS! These relationships/connections can give you valuable insights into different career paths or specific fields of study. They can also create a strong support network throughout your university life! It just feels great to know that you are not alone when it comes to navigating exams, assignments, and everything in between.

How did you first become interested in Nutritional Sciences?

I’ve always been passionate about food, and watching those cooking videos on YouTube has definitely spiked my interest in learning how nutrition comes into play in the food we eat in our daily life. On top of that, my mom has always encouraged healthy eating habits in our family, which definitely influenced my passion for learning more about food and nutrition. That’s what led me to pursue a deeper, more scientific understanding of it here at UBC.

What has been your favourite course and why? 

I have quite a few favourite courses and it’s really hard to pick just one! I think for now it would be FNH 342 Critical Perspectives on Consumer Food Practices! I enjoyed learning about the different perspectives affecting individual food choices, which includes perceptions on healthy eating, family structure, gender identity and more! This course has shown me that many factors shape one’s perception of healthy eating, and also that healthy eating can’t really be defined by just using one definition. It’s an interesting course that is less heavy on the nutritional composition of food but rather focuses on perspectives of food choices in life.

What strategies would you recommend for adapting to the new university setting? 

For me, it was definitely stepping out of my comfort zone to volunteer at events. I made most of my current LFS friends through volunteering, as an LFS Orientation Leader, with the LFS ACE Team, and through LFS|US. It was such a great way to put myself out there and start building my own community. The first step is always the hardest, but it really does get easier the more you do it! Also, don’t be afraid to reach out for support because you are never alone on this journey, and there are so many resources at UBC to help you make the most of your university experience. 

How has your experience in LFS shaped your vision for your future?

My experience in LFS has really helped me build the confidence to trust in myself, both in my future career and personal life. I came to UBC as a relatively quiet and shy person, but over time, I’ve grown into someone who feels more confident speaking in public and stepping into leadership roles. My journey here hasn’t always been smooth, but every challenge or setback became an opportunity for growth. Each ‘hiccup’ taught me that I’m capable of overcoming obstacles (and I did!). That’s what makes me feel excited and positive about what’s ahead in life for me! 

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Postdoctoral Fellow in Environmental Microbiology and Genomics

Postdoctoral Fellow in Environmental Microbiology and Genomics

Posted on March 27, 2025

The Food Nutrition and Health Program at the University of British Columbia in Vancouver, Canada, invites applications for a Postdoctoral Fellow (PDF) to join the Wine Research Centre in collaboration with Renaissance Bioscience Corp. (https://www.renaissancebioscience.com/), under the supervision of Dr. Vivien Measday (https://measday-lab.landfood.ubc.ca/). The Faculty of Land and Food Systems is located in beautiful city of Vancouver, BC Canada. The successful candidate will join a dynamic team of researchers with access to state-of-the-art facilities, and opportunities to collaborate with leading experts in academia and industry. This will be a two-year position, with an expected start date of September 1, 2025.

Overview

The PDF will make a vital contribution to the funded project entitled: “From Ecosystems to Industry: Integrating Genomic, Metabolomic, and Phenomics Tools to Capture the Genetic Diversity and Commercial Potential of Wild Yeast”. This project focuses on harnessing wild yeast diversity to establish genotype to phenotype links for a range of phenotypic traits with commercial applications. The candidate will conduct cutting-edge research in environmental microbiology and genomics while interacting closely with both academic and industry partners to help translate discoveries into innovative commercial products.

Specific activities include:

  • Harnessing and characterizing natural yeast diversity through advanced genomic, metabolomic, and phenotypic analyses.
  • Designing and implementing high-throughput phenotypic and enzymatic screening assays for various activities of interest utilizing lab automation technologies.
  • Analyzing large-scale datasets generated from high-throughput phenotypic experiments to identify yeast strains with commercially desirable traits.
  • Developing bioinformatic and machine learning pipelines to identify key genetic signatures associated with commercial metabolic activities.
  • Collaborating closely with academic and industrial partners to align research objectives with commercial goals.
  • Preparing research reports, manuscripts, and presentations for academic and industry stakeholders.

Qualifications and Experience

  • PhD in microbiology, biochemistry, genetics, molecular biology, cell biology, or a related life science field.
  • Comprehensive technical expertise in microbiology, microbial ecology, and molecular biology, including sterile techniques, yeast cell culturing, DNA extractions, and PCR.
  • Proven experience in designing and executing biochemical assays for phenotypic and enzymatic screening. Familiarity working with lab automation equipment, such as liquid handling and colony picking robotics is highly desirable. 
  • Proficiency in analyzing large-scale datasets from high-throughput experiments.
  • Strong scientific creativity, problem-solving skills, and the ability to think independently.
  • Exemplary teamwork, collaboration, and communication (verbal and written English) skills
  • Strong scientific writing skills (publications, patents).

Preferred qualifications

  • Proficiency in programming (e.g., R) and bioinformatics analysis for genomic datasets.
  • Familiarity with omics approaches, including genomic, transcriptomic, and metabolomic analyses.
  • Experience with developing and applying machine learning algorithms to analyze biological data.

The expected pay range for this position is $65,000-70,000 per year plus benefits. Salary is competitive and commensurate with education and experience.

Application Process

Interested applicants should submit a one-page statement of interest letter, a curriculum vitae (CV) including a list of publications, and contact details for 3 references by April 30, 2025 to https://ubc.wd10.myworkdayjobs.com/.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person. All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority.